The guideline provides an overview of the application areas and the benefits of simulation techniques which can be applied in the life cycle of a machine. The user receives instructions for easy selection of suitable simulation approaches for his particular task. The guideline deals with the requirements for the use of simulation, describes its application and provides instructions for successful application. It also gives simulation users a better understanding of ancillary areas and the various interactions which can occur. Of particular interest is the combination of different simulation approaches. Options for integration and continuity are also outlined here.